A phase I dose-escalation, safety and pharmacokinetic study of the 2-methoxyestradiol analog ENMD-1198 administered orally to patients with advanced cancer

BACKGROUND: 2-methoxyestradiol (2ME2) is an estradiol-17β metabolite with antiproliferative and antiangiogenic activities. ENMD-1198 is an analog of 2ME2 which was developed to decrease the metabolism and increase both the bioavailability and antitumor activities of the parent molecule. This first-i...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:Invest New Drugs
Hoofdauteurs: Zhou, Qing, Gustafson, Daniel, Nallapareddy, Sujatha, Diab, Sami, Leong, Stephen, Lewis, Karl, Gore, Lia, Messersmith, Wells A., Treston, Anthony M., Eckhardt, S. Gail, Sidor, Carolyn, Camidge, D. Ross
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2010
Onderwerpen:
Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4331064/
https://ncbi.nlm.nih.gov/pubmed/20084425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-009-9383-9
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items