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Dynamic loading and redistribution of the Mcm2-7 helicase complex through the cell cycle
Eukaryotic replication origins are defined by the ORC-dependent loading of the Mcm2-7 helicase complex onto chromatin in G1. Paradoxically, there is a vast excess of Mcm2-7 relative to ORC assembled onto chromatin in G1. These excess Mcm2-7 complexes exhibit little co-localization with ORC or replic...
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| Veröffentlicht in: | EMBO J |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BlackWell Publishing Ltd
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4331006/ https://ncbi.nlm.nih.gov/pubmed/25555795 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201488307 |
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