Drosophila ORC localizes to open chromatin and marks sites of cohesin complex loading

The origin recognition complex (ORC) is an essential DNA replication initiation factor conserved in all eukaryotes. In Saccharomyces cerevisiae, ORC binds to specific DNA elements; however, in higher eukaryotes, ORC exhibits little sequence specificity in vitro or in vivo. We investigated the genome...

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Main Authors: MacAlpine, Heather K., Gordân, Raluca, Powell, Sara K., Hartemink, Alexander J., MacAlpine, David M.
格式: Artigo
語言:Inglês
出版: Cold Spring Harbor Laboratory Press 2010
主題:
Letter
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2813476/
https://ncbi.nlm.nih.gov/pubmed/19996087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.097873.109
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