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Src phosphorylation converts Mdm2 from a ubiquitinating to a neddylating E3 ligase
Murine double minute-2 protein (Mdm2) is a multifaceted phosphorylated protein that plays a role in regulating numerous proteins including the tumor suppressor protein p53. Mdm2 binds to and is involved in conjugating either ubiquitin or Nedd8 (Neural precursor cell expressed, developmentally down-r...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4330765/ https://ncbi.nlm.nih.gov/pubmed/25624478 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1416656112 |
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