Serdemetan Antagonizes the Mdm2-HIF1α Axis Leading to Decreased Levels of Glycolytic Enzymes

Serdemetan (JNJ-26854165), an antagonist to Mdm2, was anticipated to promote the activation of p53. While regulation of p53 by Mdm2 is important, Mdm2 also regulates numerous proteins involved in diverse cellular functions. We investigated if Serdemetan would alter the Mdm2-HIF1α axis and affect cel...

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Detalhes bibliográficos
Main Authors: Lehman, Jason A., Hauck, Paula M., Gendron, Jaimie M., Batuello, Christopher N., Eitel, Jacob A., Albig, Allan, Kadakia, Madhavi P., Mayo, Lindsey D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3765416/
https://ncbi.nlm.nih.gov/pubmed/24040331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0074741
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