Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices

Activating mutations in the Kirsten rat sarcoma viral oncogene homolog (KRAS) underlie the pathogenesis and chemoresistance of ∼30% of all human tumors, yet the development of high-affinity inhibitors that target the broad range of KRAS mutants remains a formidable challenge. Here, we report the dev...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Leshchiner, Elizaveta S., Parkhitko, Andrey, Bird, Gregory H., Luccarelli, James, Bellairs, Joseph A., Escudero, Silvia, Opoku-Nsiah, Kwadwo, Godes, Marina, Perrimon, Norbert, Walensky, Loren D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2015
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4330742/
https://ncbi.nlm.nih.gov/pubmed/25624485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1413185112
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