A phase 1 study of the heat shock protein 90 inhibitor retaspimycin hydrochloride (IPI-504) in patients with gastrointestinal stromal tumors or soft tissue sarcomas

PURPOSE: Heat shock protein 90 (Hsp90) is required for the proper folding, function, and stability of various client proteins, two of which (KIT and PDGFRα) are critical in the pathogenesis and progression of gastrointestinal stromal tumors (GIST). This phase 1 study investigated the safety and maxi...

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Vydáno v:Clin Cancer Res
Hlavní autoři: Wagner, Andrew J., Chugh, Rashmi, Rosen, Lee S., Morgan, Jeffrey A., George, Suzanne, Gordon, Michael, Dunbar, Joi, Normant, Emmanuel, Grayzel, David, Demetri, George D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4330562/
https://ncbi.nlm.nih.gov/pubmed/24045182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-0953
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