A phase 1 study of the heat shock protein 90 inhibitor retaspimycin hydrochloride (IPI-504) in patients with gastrointestinal stromal tumors or soft tissue sarcomas

PURPOSE: Heat shock protein 90 (Hsp90) is required for the proper folding, function, and stability of various client proteins, two of which (KIT and PDGFRα) are critical in the pathogenesis and progression of gastrointestinal stromal tumors (GIST). This phase 1 study investigated the safety and maxi...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Wagner, Andrew J., Chugh, Rashmi, Rosen, Lee S., Morgan, Jeffrey A., George, Suzanne, Gordon, Michael, Dunbar, Joi, Normant, Emmanuel, Grayzel, David, Demetri, George D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4330562/
https://ncbi.nlm.nih.gov/pubmed/24045182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-0953
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