Development of 17-allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride (IPI-504), an anti-cancer agent directed against Hsp90

Heat shock protein 90 (Hsp90) is an emerging therapeutic target of interest for the treatment of cancer. Its role in protein homeostasis and the selective chaperoning of key signaling proteins in cancer survival and proliferation pathways has made it an attractive target of small molecule therapeuti...

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Bibliografiska uppgifter
Huvudupphovsmän: Sydor, Jens R., Normant, Emmanuel, Pien, Christine S., Porter, James R., Ge, Jie, Grenier, Louis, Pak, Roger H., Ali, Janid A., Dembski, Marlene S., Hudak, Jebecka, Patterson, Jon, Penders, Courtney, Pink, Melissa, Read, Margaret A., Sang, Jim, Woodward, Caroline, Zhang, Yilong, Grayzel, David S., Wright, Jim, Barrett, John A., Palombella, Vito J., Adams, Julian, Tong, Jeffrey K.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2006
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1635022/
https://ncbi.nlm.nih.gov/pubmed/17090671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0608372103
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