DNA lesion identity drives choice of damage tolerance pathway in murine cell chromosomes

DNA-damage tolerance (DDT) via translesion DNA synthesis (TLS) or homology-dependent repair (HDR) functions to bypass DNA lesions encountered during replication, and is critical for maintaining genome stability. Here, we present piggyBlock, a new chromosomal assay that, using piggyBac transposition...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Cohen, Isadora S., Bar, Carmit, Paz-Elizur, Tamar, Ainbinder, Elena, Leopold, Karoline, de Wind, Niels, Geacintov, Nicholas, Livneh, Zvi
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4330363/
https://ncbi.nlm.nih.gov/pubmed/25589543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1398
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