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Translesion DNA synthesis-assisted non-homologous end-joining of complex double-strand breaks prevents loss of DNA sequences in mammalian cells

Double strand breaks (DSB) are severe DNA lesions, and if not properly repaired, may lead to cell death or cancer. While there is considerable data on the repair of simple DSB (sDSB) by non-homologous end-joining (NHEJ), little is known about the repair of complex DSBs (cDSB), namely breaks with a n...

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書誌詳細
主要な著者: Covo, Shay, de Villartay, Jean-Pierre, Jeggo, Penny A., Livneh, Zvi
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2777433/
https://ncbi.nlm.nih.gov/pubmed/19762482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp703
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