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Genomic assay reveals tolerance of DNA damage by both translesion DNA synthesis and homology-dependent repair in mammalian cells

DNA lesions can block replication forks and lead to the formation of single-stranded gaps. These replication complications are mitigated by DNA damage tolerance mechanisms, which prevent deleterious outcomes such as cell death, genomic instability, and carcinogenesis. The two main tolerance strategi...

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Detaylı Bibliyografya
Asıl Yazarlar: Izhar, Lior, Ziv, Omer, Cohen, Isadora S., Geacintov, Nicholas E., Livneh, Zvi
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2013
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3631627/
https://ncbi.nlm.nih.gov/pubmed/23530190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1216894110
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