Nalaganje...
Multi-kilobase homozygous targeted gene replacement in human induced pluripotent stem cells
Sequence-specific nucleases such as TALEN and the CRISPR/Cas9 system have so far been used to disrupt, correct or insert transgenes at precise locations in mammalian genomes. We demonstrate efficient ‘knock-in’ targeted replacement of multi-kilobase genes in human induced pluripotent stem cells (iPS...
Shranjeno v:
| izdano v: | Nucleic Acids Res |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
2015
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4330342/ https://ncbi.nlm.nih.gov/pubmed/25414332 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1246 |
| Oznake: |
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