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Multi-kilobase homozygous targeted gene replacement in human induced pluripotent stem cells
Sequence-specific nucleases such as TALEN and the CRISPR/Cas9 system have so far been used to disrupt, correct or insert transgenes at precise locations in mammalian genomes. We demonstrate efficient ‘knock-in’ targeted replacement of multi-kilobase genes in human induced pluripotent stem cells (iPS...
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4330342/ https://ncbi.nlm.nih.gov/pubmed/25414332 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1246 |
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