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Competitive Binding of a Benzimidazole to the Histone-Binding Pocket of the Pygo PHD Finger
[Image: see text] The Pygo-BCL9 complex is a chromatin reader, facilitating β-catenin-mediated oncogenesis, and is thus emerging as a potential therapeutic target for cancer. Its function relies on two ligand-binding surfaces of Pygo’s PHD finger that anchor the histone H3 tail methylated at lysine...
Kaydedildi:
| Yayımlandı: | ACS Chem Biol |
|---|---|
| Asıl Yazarlar: | , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
American Chemical
Society
2014
|
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4330097/ https://ncbi.nlm.nih.gov/pubmed/25323450 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb500585s |
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