Evolutionary Adaptation of the Fly Pygo PHD Finger toward Recognizing Histone H3 Tail Methylated at Arginine 2

Pygo proteins promote Armadillo- and β-catenin-dependent transcription, by relieving Groucho-dependent repression of Wnt targets. Their PHD fingers bind histone H3 tail methylated at lysine 4, and to the HD1 domain of their Legless/BCL9 cofactors, linking Pygo to Armadillo/β-catenin. Intriguingly, f...

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Hlavní autoři: Miller, Thomas C.R., Mieszczanek, Juliusz, Sánchez-Barrena, María José, Rutherford, Trevor J., Fiedler, Marc, Bienz, Mariann
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3851687/
https://ncbi.nlm.nih.gov/pubmed/24183574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2013.09.013
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