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Single-step generation of rabbits carrying a targeted allele of the tyrosinase gene using CRISPR/Cas9

Targeted genome editing of nonrodent mammalian species has provided the potential for highly accurate interventions into gene function in humans and the generation of useful animal models of human diseases. Here we show successful clustered regularly interspaced short palindromic repeat (CRISPR) and...

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Detalhes bibliográficos
Publicado no:Exp Anim
Principais autores: Honda, Arata, Hirose, Michiko, Sankai, Tadashi, Yasmin, Lubna, Yuzawa, Kazuaki, Honsho, Kimiko, Izu, Haruna, Iguchi, Atsushi, Ikawa, Masahito, Ogura, Atsuo
Formato: Artigo
Idioma:Inglês
Publicado em: Japanese Association for Laboratory Animal Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4329513/
https://ncbi.nlm.nih.gov/pubmed/25195632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1538/expanim.14-0034
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