Single-step generation of rabbits carrying a targeted allele of the tyrosinase gene using CRISPR/Cas9

Targeted genome editing of nonrodent mammalian species has provided the potential for highly accurate interventions into gene function in humans and the generation of useful animal models of human diseases. Here we show successful clustered regularly interspaced short palindromic repeat (CRISPR) and...

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Bibliographische Detailangaben
Veröffentlicht in:Exp Anim
Hauptverfasser: Honda, Arata, Hirose, Michiko, Sankai, Tadashi, Yasmin, Lubna, Yuzawa, Kazuaki, Honsho, Kimiko, Izu, Haruna, Iguchi, Atsushi, Ikawa, Masahito, Ogura, Atsuo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Japanese Association for Laboratory Animal Science 2014
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4329513/
https://ncbi.nlm.nih.gov/pubmed/25195632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1538/expanim.14-0034
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