Single-step generation of rabbits carrying a targeted allele of the tyrosinase gene using CRISPR/Cas9

Targeted genome editing of nonrodent mammalian species has provided the potential for highly accurate interventions into gene function in humans and the generation of useful animal models of human diseases. Here we show successful clustered regularly interspaced short palindromic repeat (CRISPR) and...

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Bibliografiske detaljer
Udgivet i:Exp Anim
Main Authors: Honda, Arata, Hirose, Michiko, Sankai, Tadashi, Yasmin, Lubna, Yuzawa, Kazuaki, Honsho, Kimiko, Izu, Haruna, Iguchi, Atsushi, Ikawa, Masahito, Ogura, Atsuo
Format: Artigo
Sprog:Inglês
Udgivet: Japanese Association for Laboratory Animal Science 2014
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Original
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4329513/
https://ncbi.nlm.nih.gov/pubmed/25195632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1538/expanim.14-0034
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