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Single-step generation of rabbits carrying a targeted allele of the tyrosinase gene using CRISPR/Cas9

Targeted genome editing of nonrodent mammalian species has provided the potential for highly accurate interventions into gene function in humans and the generation of useful animal models of human diseases. Here we show successful clustered regularly interspaced short palindromic repeat (CRISPR) and...

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Détails bibliographiques
Publié dans:Exp Anim
Auteurs principaux: Honda, Arata, Hirose, Michiko, Sankai, Tadashi, Yasmin, Lubna, Yuzawa, Kazuaki, Honsho, Kimiko, Izu, Haruna, Iguchi, Atsushi, Ikawa, Masahito, Ogura, Atsuo
Format: Artigo
Langue:Inglês
Publié: Japanese Association for Laboratory Animal Science 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4329513/
https://ncbi.nlm.nih.gov/pubmed/25195632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1538/expanim.14-0034
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