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Antisense-mediated angiotensinogen inhibition slows polycystic kidney disease in mice with a targeted mutation in Pkd2

Renal cyst enlargement is associated with the activation of both the circulating and intrarenal renin-angiotensin systems. Angiotensinogen (AGT) is the substrate for renin. The aim of the present study was to determine the effect of AGT inhibition on renal cyst enlargement. An AGT antisense oligonuc...

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Pubblicato in:Am J Physiol Renal Physiol
Autori principali: Ravichandran, Kameswaran, Ozkok, Abdullah, Wang, Qian, Mullick, Adam E., Edelstein, Charles L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4329486/
https://ncbi.nlm.nih.gov/pubmed/25537744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00478.2014
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