Hypoxia-inducible factor-1α (HIF-1α) and autophagy in polycystic kidney disease (PKD)

Cyst expansion in polycystic kidney disease (PKD) results in localized hypoxia in the kidney that may activate hypoxia-inducible factor-1α (HIF-1α). HIF-1α and autophagy, a form of programmed cell repair, are induced by hypoxia. The purposes were to determine HIF-1α expression and autophagy in rat a...

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Main Authors: Belibi, Franck, Zafar, Iram, Ravichandran, Kameswaran, Segvic, Anamarija Bauer, Jani, Alkesh, Ljubanovic, Danica Galesic, Edelstein, Charles L.
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2011
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3094047/
https://ncbi.nlm.nih.gov/pubmed/21270095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00348.2010
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