Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis

Pathological fibrosis is driven by a feedback loop in which the fibrotic extracellular matrix is both a cause and consequence of fibroblast activation. However, the molecular mechanisms underlying this process remain poorly understood. Here we identify yes-associated protein (YAP) (homolog of drosop...

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Détails bibliographiques
Publié dans:Am J Physiol Lung Cell Mol Physiol
Auteurs principaux: Liu, Fei, Lagares, David, Choi, Kyoung Moo, Stopfer, Lauren, Marinković, Aleksandar, Vrbanac, Vladimir, Probst, Clemens K., Hiemer, Samantha E., Sisson, Thomas H., Horowitz, Jeffrey C., Rosas, Ivan O., Fredenburgh, Laura E., Feghali-Bostwick, Carol, Varelas, Xaralabos, Tager, Andrew M., Tschumperlin, Daniel J.
Format: Artigo
Langue:Inglês
Publié: American Physiological Society 2014
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4329470/
https://ncbi.nlm.nih.gov/pubmed/25502501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00300.2014
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