Pulmonary artery smooth muscle cell endothelin-1 expression modulates the pulmonary vascular response to chronic hypoxia

Endothelin-1 (ET-1) increases pulmonary vascular tone through direct effects on pulmonary artery smooth muscle cells (PASMC) via membrane-bound ET-1 receptors. Circulating ET-1 contributes to vascular remodeling by promoting SMC proliferation and migration and inhibiting SMC apoptosis. Although endo...

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Pubblicato in:Am J Physiol Lung Cell Mol Physiol
Autori principali: Kim, Francis Y., Barnes, Elizabeth A., Ying, Lihua, Chen, Chihhsin, Lee, Lori, Alvira, Cristina M., Cornfield, David N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4329469/
https://ncbi.nlm.nih.gov/pubmed/25399435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00253.2014
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