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Hypoxia Inducible Factor-1α in Pulmonary Artery Smooth Muscle Cells Lowers Vascular Tone by Decreasing Myosin Light Chain Phosphorylation

RATIONALE: Hypoxia inducible factor-1α HIF-1α an oxygen (O(2))-sensitive transcription factor, mediates transcriptional responses to low O(2) tension states. While acute hypoxia causes pulmonary vasoconstriction and chronic hypoxia can cause vascular remodeling and pulmonary hypertension, conflictin...

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Bibliografiske detaljer
Main Authors: Kim, Yu-Mee, Barnes, Elizabeth A., Alvira, Cristina M., Ying, Lihua, Reddy, Sushma, Cornfield, David N.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4005857/
https://ncbi.nlm.nih.gov/pubmed/23513056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.112.300646
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