Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1

Telomere maintenance by telomerase is impaired in the stem cell disease dyskeratosis congenita and during human aging. Telomerase depends upon a complex pathway for enzyme assembly, localization in Cajal bodies and association with telomeres. Here, we identify the chaperonin CCT/TRiC as a critical r...

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Bibliographic Details
Published in:Cell
Main Authors: Freund, Adam, Zhong, Franklin L., Venteicher, Andrew S., Meng, Zhaojing, Veenstra, Timothy D., Frydman, Judith, Artandi, Steven E.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4329143/
https://ncbi.nlm.nih.gov/pubmed/25467444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.10.059
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