An activity switch in human telomerase based on RNA conformation and shaped by TCAB1

Ribonucleoprotein enzymes require dynamic conformations of their RNA constituents for regulated catalysis. Human telomerase employs a non-coding RNA (hTR) with a bipartite arrangement of domains - a template-containing core and a distal three-way junction (CR4/5) that stimulates catalysis through un...

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Udgivet i:Cell
Main Authors: Chen, Lu, Roake, Caitlin M., Freund, Adam, Batista, Pedro J., Tian, Siqi, Yin, Yi A., Gajera, Chandresh R., Lin, Shengda, Lee, Byron, Pech, Matthew F., Venteicher, Andrew S., Das, Rhiju, Chang, Howard Y., Artandi, Steven E.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6063371/
https://ncbi.nlm.nih.gov/pubmed/29804836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.04.039
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