Modeling alveolar soft part sarcomagenesis in the mouse: a role for lactate in the tumor microenvironment

Alveolar soft part sarcoma (ASPS), a deadly soft tissue malignancy with a predilection for adolescents and young adults, associates consistently with t(X;17) translocations that generate the fusion gene ASPSCR1-TFE3. We proved the oncogenic capacity of this fusion gene by driving sarcomagenesis in m...

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Vydáno v:Cancer Cell
Hlavní autoři: Goodwin, Matthew L., Jin, Huifeng, Straessler, Krystal, Smith-Fry, Kyllie, Zhu, Ju-Fen, Monument, Michael J., Grossmann, Allie, Randall, R. Lor, Capecchi, Mario R., Jones, Kevin B.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4327935/
https://ncbi.nlm.nih.gov/pubmed/25453902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2014.10.003
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