Coexistent hyperdiploidy does not abrogate poor prognosis in myeloma with adverse cytogenetics and may precede IGH translocations

The acquisition of the cytogenetic abnormalities hyperdiploidy or translocations into the immunoglobulin gene loci are considered as initiating events in the pathogenesis of myeloma and were often assumed to be mutually exclusive. These lesions have clinical significance; hyperdiploidy or the presen...

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Publicado en:Blood
Autores principales: Pawlyn, Charlotte, Melchor, Lorenzo, Murison, Alex, Wardell, Christopher P., Brioli, Annamaria, Boyle, Eileen M., Kaiser, Martin F., Walker, Brian A., Begum, Dil B., Dahir, Nasrin B., Proszek, Paula, Gregory, Walter M., Drayson, Mark T., Jackson, Graham H., Ross, Fiona M., Davies, Faith E., Morgan, Gareth J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2015
Materias:
Lymphoid Neoplasia
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4327151/
https://ncbi.nlm.nih.gov/pubmed/25428216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-07-584268
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