Mutational Spectrum, Copy Number Changes, and Outcome: Results of a Sequencing Study of Patients With Newly Diagnosed Myeloma

PURPOSE: At the molecular level myeloma is characterised by copy number abnormalities and recurrent translocations into the immunoglobulin heavy chain (IGH) locus. Novel methodologies such as massively parallel sequencing have begun to describe the pattern of tumour acquired mutations but their clin...

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Published in:J Clin Oncol
Main Authors: Walker, Brian A, Boyle, Eileen M, Wardell, Christopher P, Murison, Alex, Begum, Dil B, Dahir, Nasrin B, Proszek, Paula Z, Johnson, David C, Kaiser, Martin F, Melchor, Lorenzo, Aronson, Lauren I., Pawlyn, Charlotte, Mirabella, F, Jones, John R., Brioli, Annamaria, Mikulasova, Aneta, Leleu, Xavier, Cairns, David A, Gregory, Walter, Quartilho, A, Drayson, Mark T, Russell, Nigel, Cook, Gordon, Jackson, Graham H, Davies, Faith E, Morgan, Gareth J
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6485456/
https://ncbi.nlm.nih.gov/pubmed/26282654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2014.59.1503
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