APOBEC family mutational signatures are associated with poor prognosis translocations in multiple myeloma

We have sequenced 463 presenting cases of myeloma entered into the UK Myeloma XI study using whole exome sequencing. Here we identify mutations induced as a consequence of misdirected AID in the partner oncogenes of IGH translocations, which are activating and associated with impaired clinical outco...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Walker, Brian A, Wardell, Christopher P, Murison, Alex, Boyle, Eileen M, Begum, Dil B, Dahir, Nasrin M, Proszek, Paula Z, Melchor, Lorenzo, Pawlyn, Charlotte, Kaiser, Martin F, Johnson, David C, Qiang, Ya-Wei, Jones, John R, Cairns, David A, Gregory, Walter M, Owen, Roger G, Cook, Gordon, Drayson, Mark T, Jackson, Graham H, Davies, Faith E, Morgan, Gareth J
Format: Artigo
Jezik:Inglês
Izdano: 2015
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4568299/
https://ncbi.nlm.nih.gov/pubmed/25904160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7997
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