APOBEC family mutational signatures are associated with poor prognosis translocations in multiple myeloma

We have sequenced 463 presenting cases of myeloma entered into the UK Myeloma XI study using whole exome sequencing. Here we identify mutations induced as a consequence of misdirected AID in the partner oncogenes of IGH translocations, which are activating and associated with impaired clinical outco...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Walker, Brian A, Wardell, Christopher P, Murison, Alex, Boyle, Eileen M, Begum, Dil B, Dahir, Nasrin M, Proszek, Paula Z, Melchor, Lorenzo, Pawlyn, Charlotte, Kaiser, Martin F, Johnson, David C, Qiang, Ya-Wei, Jones, John R, Cairns, David A, Gregory, Walter M, Owen, Roger G, Cook, Gordon, Drayson, Mark T, Jackson, Graham H, Davies, Faith E, Morgan, Gareth J
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4568299/
https://ncbi.nlm.nih.gov/pubmed/25904160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7997
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