APOBEC family mutational signatures are associated with poor prognosis translocations in multiple myeloma

We have sequenced 463 presenting cases of myeloma entered into the UK Myeloma XI study using whole exome sequencing. Here we identify mutations induced as a consequence of misdirected AID in the partner oncogenes of IGH translocations, which are activating and associated with impaired clinical outco...

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Pubblicato in:Nat Commun
Autori principali: Walker, Brian A, Wardell, Christopher P, Murison, Alex, Boyle, Eileen M, Begum, Dil B, Dahir, Nasrin M, Proszek, Paula Z, Melchor, Lorenzo, Pawlyn, Charlotte, Kaiser, Martin F, Johnson, David C, Qiang, Ya-Wei, Jones, John R, Cairns, David A, Gregory, Walter M, Owen, Roger G, Cook, Gordon, Drayson, Mark T, Jackson, Graham H, Davies, Faith E, Morgan, Gareth J
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4568299/
https://ncbi.nlm.nih.gov/pubmed/25904160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7997
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