APOBEC family mutational signatures are associated with poor prognosis translocations in multiple myeloma

We have sequenced 463 presenting cases of myeloma entered into the UK Myeloma XI study using whole exome sequencing. Here we identify mutations induced as a consequence of misdirected AID in the partner oncogenes of IGH translocations, which are activating and associated with impaired clinical outco...

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Vydáno v:Nat Commun
Hlavní autoři: Walker, Brian A, Wardell, Christopher P, Murison, Alex, Boyle, Eileen M, Begum, Dil B, Dahir, Nasrin M, Proszek, Paula Z, Melchor, Lorenzo, Pawlyn, Charlotte, Kaiser, Martin F, Johnson, David C, Qiang, Ya-Wei, Jones, John R, Cairns, David A, Gregory, Walter M, Owen, Roger G, Cook, Gordon, Drayson, Mark T, Jackson, Graham H, Davies, Faith E, Morgan, Gareth J
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4568299/
https://ncbi.nlm.nih.gov/pubmed/25904160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7997
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