Collagenase-resistant collagen promotes mouse aging and vascular cell senescence

Collagen fibrils become resistant to cleavage over time. We hypothesized that resistance to type I collagen proteolysis not only marks biological aging but also drives it. To test this, we followed mice with a targeted mutation (Col1a1(r/r)) that yields collagenase-resistant type I collagen. Compare...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Vafaie, Faran, Yin, Hao, O’Neil, Caroline, Nong, Zengxuan, Watson, Alanna, Arpino, John-Michael, Chu, Michael W A, Wayne Holdsworth, David, Gros, Robert, Pickering, J Geoffrey
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326859/
https://ncbi.nlm.nih.gov/pubmed/23957394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12155
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