Type I Collagen Cleavage Is Essential for Effective Fibrotic Repair after Myocardial Infarction

Efficient deposition of type I collagen is fundamental to healing after myocardial infarction. Whether there is also a role for cleavage of type I collagen in infarct healing is unknown. To test this, we undertook coronary artery occlusion in mice with a targeted mutation (Col1a1(r/r)) that yields c...

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Detalhes bibliográficos
Main Authors: Nong, Zengxuan, O'Neil, Caroline, Lei, Ming, Gros, Robert, Watson, Alanna, Rizkalla, Amin, Mequanint, Kibret, Li, Shaohua, Frontini, Matthew J., Feng, Qingping, Pickering, J. Geoffrey
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2011
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204031/
https://ncbi.nlm.nih.gov/pubmed/21907695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.07.017
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