Synaptic Synthesis, Dephosphorylation, and Degradation: A NOVEL PARADIGM FOR AN ACTIVITY-DEPENDENT NEURONAL CONTROL OF CDKL5

Mutations in the X-linked CDKL5 (cyclin-dependent kinase-like 5) gene have been associated with several forms of neurodevelopmental disorders, including atypical Rett syndrome, autism spectrum disorders, and early infantile epileptic encephalopathy. Accordingly, loss of CDKL5 in mice results in auti...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: La Montanara, Paolo, Rusconi, Laura, Locarno, Albina, Forti, Lia, Barbiero, Isabella, Tramarin, Marco, Chandola, Chetan, Kilstrup-Nielsen, Charlotte, Landsberger, Nicoletta
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326854/
https://ncbi.nlm.nih.gov/pubmed/25555910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.589762
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