Synaptic Synthesis, Dephosphorylation, and Degradation: A NOVEL PARADIGM FOR AN ACTIVITY-DEPENDENT NEURONAL CONTROL OF CDKL5

Mutations in the X-linked CDKL5 (cyclin-dependent kinase-like 5) gene have been associated with several forms of neurodevelopmental disorders, including atypical Rett syndrome, autism spectrum disorders, and early infantile epileptic encephalopathy. Accordingly, loss of CDKL5 in mice results in auti...

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Vydáno v:J Biol Chem
Hlavní autoři: La Montanara, Paolo, Rusconi, Laura, Locarno, Albina, Forti, Lia, Barbiero, Isabella, Tramarin, Marco, Chandola, Chetan, Kilstrup-Nielsen, Charlotte, Landsberger, Nicoletta
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Neurobiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326854/
https://ncbi.nlm.nih.gov/pubmed/25555910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.589762
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