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Extrasynaptic N-Methyl-d-aspartate (NMDA) Receptor Stimulation Induces Cytoplasmic Translocation of the CDKL5 Kinase and Its Proteasomal Degradation

Mutations in the X-linked gene cyclin-dependent kinase-like 5 (CDKL5) have been found in patients with epileptic encephalopathy characterized by early onset intractable epilepsy, including infantile spasms and other types of seizures, severe developmental delay, and often the development of Rett syn...

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Détails bibliographiques
Auteurs principaux: Rusconi, Laura, Kilstrup-Nielsen, Charlotte, Landsberger, Nicoletta
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2011
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196071/
https://ncbi.nlm.nih.gov/pubmed/21832092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.235630
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