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Extrasynaptic N-Methyl-d-aspartate (NMDA) Receptor Stimulation Induces Cytoplasmic Translocation of the CDKL5 Kinase and Its Proteasomal Degradation

Mutations in the X-linked gene cyclin-dependent kinase-like 5 (CDKL5) have been found in patients with epileptic encephalopathy characterized by early onset intractable epilepsy, including infantile spasms and other types of seizures, severe developmental delay, and often the development of Rett syn...

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Autors principals: Rusconi, Laura, Kilstrup-Nielsen, Charlotte, Landsberger, Nicoletta
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196071/
https://ncbi.nlm.nih.gov/pubmed/21832092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.235630
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