CDKL5 Expression Is Modulated during Neuronal Development and Its Subcellular Distribution Is Tightly Regulated by the C-terminal Tail

Mutations in the human X-linked cyclin-dependent kinase-like 5 (CDKL5) gene have been identified in patients with Rett syndrome (RTT), West syndrome, and X-linked infantile spasms, sharing the common feature of mental retardation and early seizures. CDKL5 is a rather uncharacterized kinase, but its...

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Main Authors: Rusconi, Laura, Salvatoni, Lisa, Giudici, Laura, Bertani, Ilaria, Kilstrup-Nielsen, Charlotte, Broccoli, Vania, Landsberger, Nicoletta
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Molecular Basis of Cell and Developmental Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662074/
https://ncbi.nlm.nih.gov/pubmed/18701457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804613200
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