Protein-tyrosine Phosphatase Shp2 Positively Regulates Macrophage Oxidative Burst

Macrophages are vital to innate immunity and express pattern recognition receptors and integrins for the rapid detection of invading pathogens. Stimulation of Dectin-1 and complement receptor 3 (CR3) activates Erk- and Akt-dependent production of reactive oxygen species (ROS). Shp2, a protein-tyrosi...

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Bibliografski detalji
Izdano u:J Biol Chem
Glavni autori: Li, Xing Jun, Goodwin, Charles B, Nabinger, Sarah C., Richine, Briana M., Yang, Zhenyun, Hanenberg, Helmut, Ohnishi, Hiroshi, Matozaki, Takashi, Feng, Gen-Sheng, Chan, Rebecca J.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2015
Teme:
Molecular Bases of Disease
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326800/
https://ncbi.nlm.nih.gov/pubmed/25538234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.614057
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