Protein-tyrosine Phosphatase Shp2 Positively Regulates Macrophage Oxidative Burst

Macrophages are vital to innate immunity and express pattern recognition receptors and integrins for the rapid detection of invading pathogens. Stimulation of Dectin-1 and complement receptor 3 (CR3) activates Erk- and Akt-dependent production of reactive oxygen species (ROS). Shp2, a protein-tyrosi...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Li, Xing Jun, Goodwin, Charles B, Nabinger, Sarah C., Richine, Briana M., Yang, Zhenyun, Hanenberg, Helmut, Ohnishi, Hiroshi, Matozaki, Takashi, Feng, Gen-Sheng, Chan, Rebecca J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2015
Materias:
Molecular Bases of Disease
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326800/
https://ncbi.nlm.nih.gov/pubmed/25538234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.614057
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