Protein-tyrosine Phosphatase Shp2 Positively Regulates Macrophage Oxidative Burst

Macrophages are vital to innate immunity and express pattern recognition receptors and integrins for the rapid detection of invading pathogens. Stimulation of Dectin-1 and complement receptor 3 (CR3) activates Erk- and Akt-dependent production of reactive oxygen species (ROS). Shp2, a protein-tyrosi...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Li, Xing Jun, Goodwin, Charles B, Nabinger, Sarah C., Richine, Briana M., Yang, Zhenyun, Hanenberg, Helmut, Ohnishi, Hiroshi, Matozaki, Takashi, Feng, Gen-Sheng, Chan, Rebecca J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2015
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326800/
https://ncbi.nlm.nih.gov/pubmed/25538234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.614057
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