Calpain inhibition mediates autophagy-dependent protection against polyglutamine toxicity

Over recent years, accumulated evidence suggests that autophagy induction is protective in animal models of a number of neurodegenerative diseases. Intense research in the field has elucidated different pathways through which autophagy can be upregulated and it is important to establish how modulati...

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Veröffentlicht in:Cell Death Differ
Hauptverfasser: Menzies, F M, Garcia-Arencibia, M, Imarisio, S, O'Sullivan, N C, Ricketts, T, Kent, B A, Rao, M V, Lam, W, Green-Thompson, Z W, Nixon, R A, Saksida, L M, Bussey, T J, O'Kane, C J, Rubinsztein, D C
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
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Original Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326573/
https://ncbi.nlm.nih.gov/pubmed/25257175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.151
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