AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1

Damaged mitochondria are eliminated by mitophagy, a selective form of autophagy whose dysfunction associates with neurodegenerative diseases. PINK1, PARKIN and p62/SQTMS1 have been shown to regulate mitophagy, leaving hitherto ill-defined the contribution by key players in ‘general' autophagy....

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Publicat a:Cell Death Differ
Autors principals: Strappazzon, F, Nazio, F, Corrado, M, Cianfanelli, V, Romagnoli, A, Fimia, G M, Campello, S, Nardacci, R, Piacentini, M, Campanella, M, Cecconi, F
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
Matèries:
Original Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326570/
https://ncbi.nlm.nih.gov/pubmed/25215947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.139
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