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Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy
BECLIN 1 is a central player in macroautophagy. AMBRA1, a BECLIN 1-interacting protein, positively regulates the BECLIN 1-dependent programme of autophagy. In this study, we show that AMBRA1 binds preferentially the mitochondrial pool of the antiapoptotic factor BCL-2, and that this interaction is d...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3094111/ https://ncbi.nlm.nih.gov/pubmed/21358617 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.49 |
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