Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy

BECLIN 1 is a central player in macroautophagy. AMBRA1, a BECLIN 1-interacting protein, positively regulates the BECLIN 1-dependent programme of autophagy. In this study, we show that AMBRA1 binds preferentially the mitochondrial pool of the antiapoptotic factor BCL-2, and that this interaction is d...

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Main Authors: Strappazzon, Flavie, Vietri-Rudan, Matteo, Campello, Silvia, Nazio, Francesca, Florenzano, Fulvio, Fimia, Gian Maria, Piacentini, Mauro, Levine, Beth, Cecconi, Francesco
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3094111/
https://ncbi.nlm.nih.gov/pubmed/21358617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.49
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