Prosurvival AMBRA1 turns into a proapoptotic BH3-like protein during mitochondrial apoptosis

Autophagy and apoptosis are 2 stress-response mechanisms that are closely interconnected. However, the molecular interplays between these 2 pathways remain to be clarified. Here we report that the crucial proautophagic factor AMBRA1 can act as a positive mediator of mitochondrial apoptosis. Indeed,...

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Bibliografiske detaljer
Udgivet i:Autophagy
Main Authors: Strappazzon, Flavie, Di Rita, Anthea, Cianfanelli, Valentina, D'Orazio, Melania, Nazio, Francesca, Fimia, Gian Maria, Cecconi, Francesco
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2016
Fag:
Basic Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4922440/
https://ncbi.nlm.nih.gov/pubmed/27123694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2016.1164359
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