miR-122 Stimulates Hepatitis C Virus RNA Synthesis by Altering the Balance of Viral RNAs Engaged in Replication versus Translation

The liver-specific microRNA, miR-122, stabilizes hepatitis C virus (HCV) RNA genomes by recruiting host argonaute 2 (AGO2) to the 5′ end and preventing decay mediated by exonuclease Xrn1. However, HCV replication requires miR-122 in Xrn1-depleted cells, indicating additional functions. We show that...

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Pubblicato in:Cell Host Microbe
Autori principali: Masaki, Takahiro, Arend, Kyle C., Li, You, Yamane, Daisuke, McGivern, David R., Kato, Takanobu, Wakita, Takaji, Moorman, Nathaniel J., Lemon, Stanley M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier Inc. 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326553/
https://ncbi.nlm.nih.gov/pubmed/25662750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2014.12.014
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