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Dissecting the Roles of the 5′ Exoribonucleases Xrn1 and Xrn2 in Restricting Hepatitis C Virus Replication

The replication of hepatitis C virus (HCV) is uniquely dependent on a host microRNA, miR-122. Previous studies using genotype 1a H77S.3 virus demonstrated that miR-122 acts in part by protecting the RNA genome from 5′ decay mediated by the cytoplasmic 5′ exoribonuclease, Xrn1. However, this finding...

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書目詳細資料
發表在:J Virol
Main Authors: Li, You, Yamane, Daisuke, Lemon, Stanley M.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403451/
https://ncbi.nlm.nih.gov/pubmed/25673723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03692-14
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