Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth

How mitochondrial glutaminolysis contributes to redox homeostasis in cancer cells remains unclear. Here we report that the mitochondrial enzyme glutamate dehydrogenase 1 (GDH1) is commonly upregulated in human cancers. GDH1 is important for redox homeostasis in cancer cells by controlling the intrac...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Cancer Cell
Päätekijät: Jin, Lingtao, Li, Dan, Alesi, Gina N., Fan, Jun, Kang, Hee-Bum, Lu, Zhou, Boggon, Titus J., Jin, Peng, Yi, Hong, Wright, Elizabeth R., Duong, Duc, Seyfried, Nicholas T., Egnatchik, Robert, DeBerardinis, Ralph J., Magliocca, Kelly R., He, Chuan, Arellano, Martha L., Khoury, Hanna J., Shin, Dong M., Khuri, Fadlo R., Kang, Sumin
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2015
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4325424/
https://ncbi.nlm.nih.gov/pubmed/25670081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2014.12.006
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia