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E3 Ubiquitin Ligases Cbl-b Regulates Thymic- Derived CD4(+)CD25(+) Regulatory T Cell Development by Targeting Foxp3 for Ubiquitination
CD28 costimulation is essential for the development of Thymic-derived CD4(+)CD25(+)Foxp3(+) regulatory T cells ("tTregs"). E3 ubiquitin ligase Cbl-b has been shown to regulate CD28 dependence of T cell activation. Here, we report that the loss of Cbl-b partially but significantly rescues t...
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| 發表在: | J Immunol |
|---|---|
| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4324371/ https://ncbi.nlm.nih.gov/pubmed/25560411 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402434 |
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