E3 Ubiquitin Ligase Cbl-b Regulates Pten via Nedd4 in T Cells Independently of Its Ubiquitin Ligase Activity

E3 ubiquitin ligase Cbl-b plays a crucial role in T cell activation and tolerance induction. However, the molecular mechanism by which Cbl-b inhibits T cell activation remains unclear. Here we report that Cbl-b does not inhibit PI3-K, but rather suppresses TCR/CD28-induced inactivation of Pten. The...

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Main Authors: Guo, Hui, Qiao, Guilin, Ying, Haiyan, Li, Zhenping, Zhao, Yixia, Liang, Yanran, Yang, Lifen, Lipkowitz, Stanley, Penninger, Josef M., Langdon, Wallace Y., Zhang, Jian
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3387815/
https://ncbi.nlm.nih.gov/pubmed/22763434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2012.04.008
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